You may be asking yourself “Why is a Pixar movie on a list of movies about depression?” but there’s a good reason for it. Peter Docter’s 2015 emotional, animated feature, Inside Out, takes a look inside the brain of a young girl named Riley whose life is completely upended when she and her parents move from the Midwest to San Francisco. Told mostly through Riley’s emotions (played by an all-star cast including Amy Poehler, Phyllis Smith, Mindy Kaling, Bill Hader, and others) the movie dives into issues ranging from loneliness to the brink of depression when the young girl’s feelings get all out of wack.

Not long after a bitter breakup, Joel Barish (Jim Carrey) learns that his ex-girlfriend Clementine Kruczynski (Kate Winslet) has taken extreme measures to get over the shattered relationship: wiping all memory of Joel and their past from her memory. Distraught and depressed by the news, Joel decides to undergo the same procedure in Michel Gondry’s 2004 transfixing Eternal Sunshine of the Spotless Mind. However, letting go is easier said than done as the heartbroken Joel begins to have second thoughts about the process and fights to save the memories (both good and bad) before they’re lost to time.

Following the death of his brother, grief-stricken loner Lee Chandler (Casey Affleck) returns to his hometown of Manchester-by-the-sea where he discovers he has become the legal guardian of his teenage nephew, Patrick (Lucas Hedges). The reason behind Lee’s bleak demeanor and departure from his family’s longtime home is not immediately revealed, but when the truth comes out, it is easy to see how someone could fall into a deep, dark abyss of depression. Also while he’s back home, Lee runs into his ex-wife Randi (Michelle Williams), leading to one of the most heartbreaking movie meltdowns in recent memory.

Sofia Coppola’s 2003 drama Lost In Translation deals more with chronic loneliness than depression, but since the two go hand-in-hand so often, the movie is more than deserving of a spot here. The film centers on Bob Harris (Bill Murray), a washed up movie star whose career has reached the point where all there is left to do is appear in Japanese commercials and drink at a Tokyo hotel bar. His life is given new meaning when he meets Charlotte (Scarlett Johansson), the wife of a famous and distracted photographer. The two unlikely friends strike up an immediate bond as they explore the sights and sounds of Tokyo and begin to learn more about themselves than they would have ever guessed.

Zach Braff’s 2004 directorial debut, Garden State, centers on struggling actor Andrew Largeman (Braff) as he returns to his family home in New Jersey to attend his mother’s funeral. While there, Andrew begins to come to terms with his role in an accident that left his mother confined to a wheelchair decades before her death and his father’s (Ian Holm) decision to put him on various antidepressants and lithium after the accident. Without giving too much away, there’s a scene near the end of the movie in which Andrew, his love interest Sam (Natalie Portman), and old friend Mark (Peter Sarsgard) visit a man guarding an abandoned quarry and Andrew tells him “Good luck exploring the infinite abyss” and the man responds with “You too.” More than a decade-and-a-half later, that moment still gets me.

Jonathan Dayton and Valerie Faris’ 2006 family road trip movie, Little Miss Sunshine, follows the Hoover family as they drive across the American Southwest so that the youngest member of the group, Olive (Abigail Breslin) can compete in a beauty pageant held in California, but the movie is about so much more than that. Sure, the central conflict that ties everyone together is road trip in that iconic yellow Volkswagen Microbus, but each family member is dealing with their own personal demons. Two of the biggest and most thoughtful of these subplots are those of Frank Ginsberg (Steve Carell), who has just been released from a mental hospital after trying to kill himself, and Dwayne Hoover (Paul Dano), who has a rather extreme mental breakdown due to a certain visual impairment. Both of these characters learn to deal with their afflictions and are made better people because of it.

David O. Russell’s 2012 romantic comedy Silver Linings Playbook tackles a myriad of different topics and mental illnesses as well as how the characters’ conditions affect practically every aspect of their lives. There’s Pat Solitano (Bradley Cooper), a recently divorced Philadelphian dealing with bipolar disorder and all the issues that stem from it, Tiffany Maxwell (Jennifer Lawrence), a grieving widow still coming to terms with her husband’s death, and Patrizio “Pat” Solitano Sr. (Robert De Niro), Pat’s father whose life is in disarray because of his OCD and gambling addiction. Each of these characters eventually come to terms with their illnesses and the depression that spawns from it in this perfectly-balanced dramedy.

Craig Johnson’s 2014 dramedy The Skeleton Twins follows Milo Dean (Bill Hader) and Maggie Dean (Kristen Wiig), a brother and sister who are brought back together after years apart just as each are experiencing their own crises. To better take care of themselves (and one another) the estranged twins begin to confront the people and situations that pushed them over the edge while also coming to terms with their own relationship and how two people who were brought into this world together could drift so far apart. And then, there’s the amazing scene where Milo and Maggie lip-sync “Nothing’s Gonna Stop Us Now.”

Stephen Chbosky’s 2012 coming-of-age drama, The Perks of Being a Wallflower (which was based on  his book of the same name), tells the story of awkward high school freshman Charlie (Logan Lerman) as breaks out of his shell and begins to explore all life has to offer after befriending a group of seniors who forever change his life. During all of this, Charlie is battling severe depression brought on by his best friend’s death as well as repressed memories from a traumatic childhood event. The film, like the book, also deals with the way in which isolation, loneliness, and an inability to express one’s true feelings can have on the mind and soul of a young teenager.

Charlie Kaufman’s sprawling and mind-bending psychological drama Synecdoche, New York follows down-on-his-luck theater director Caden Cotard (Philip Seymour Hoffman), who develops a rather unique and arguably unhealthy coping method after his wife and daughter leave him: construct and produce an elaborate stage production of his life that slowly becomes more and more complicated and blurs the lines between fiction and reality. This truly bizarre (even for Kaufman’s standards) film is as transfixing as it is convoluted, but it offers a new spin on the idea of a tortured artist finding a way in which he can block out the pain of his own life.

Released in 2011, Lars Von Tier’s Melancholia follows two sisters — Justine (Kirsten Dunst) and Claire (Charlotte Gainsbourg) — as they await their impending doom, that will be brought on when a planet crashes into Earth, wiping out all life. On top of that, Justine is in the middle of severe bout of depression brought on by the failure of her marriage in addition to other issues from throughout her life.